FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation

Mutations in the cardiac thin filament (TF) have highly variable effects on the regulatory function of the cardiac sarcomere. Understanding the molecular-level dysfunction elicited by TF mutations is crucial to elucidate cardiac disease mechanisms. The hypertrophic cardiomyopathy–causing cardiac tro...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Abdullah, Salwa, Lynn, Melissa L., McConnell, Mark T., Klass, Matthew M., Baldo, Anthony P., Schwartz, Steven D., Tardiff, Jil C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779437/
https://ncbi.nlm.nih.gov/pubmed/31387947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005098
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