Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs

A fusion between the EML4 (echinoderm microtubule-associated protein-like) and ALK (anaplastic lymphoma kinase) genes was identified in non-small cell lung cancer (NSCLC) in 2007 and there has been rapid progress in applying this knowledge to the benefit of patients. However, we have a poor understa...

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Vydáno v:Cell Mol Life Sci
Hlavní autoři: Bayliss, Richard, Choi, Jene, Fennell, Dean A., Fry, Andrew M., Richards, Mark W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2016
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761370/
https://ncbi.nlm.nih.gov/pubmed/26755435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-015-2117-6
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