Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor

Fas (CD95, Apo-1, TNFRSF6) is a prototypical apoptosis-inducing death receptor in the tumor necrosis factor receptor (TNFR) superfamily. While the extracellular domains of TNFRs form trimeric complexes with their ligands and the intracellular domains engage in higher-order oligomerization, the role...

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Publicado no:Mol Cell
Main Authors: Fu, Qingshan, Fu, Tian-Min, Cruz, Anthony C., Sengupta, Prabuddha, Thomas, Stacy K., Wang, Shuqing, Siegel, Richard M, Wu, Hao, Chou, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761300/
https://ncbi.nlm.nih.gov/pubmed/26853147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.01.009
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