Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction

Mutations affecting the apoptosis-inducing function of the Fas/CD95 TNF-family receptor result in autoimmune and lymphoproliferative disease. However, Fas can also costimulate T-cell activation and promote tumour cell growth and metastasis. Palmitoylation at a membrane proximal cysteine residue enab...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Cruz, Anthony C., Ramaswamy, Madhu, Ouyang, Claudia, Klebanoff, Christopher A., Sengupta, Prabuddha, Yamamoto, Tori N., Meylan, Françoise, Thomas, Stacy K., Richoz, Nathan, Eil, Robert, Price, Susan, Casellas, Rafael, Rao, V. Koneti, Lippincott-Schwartz, Jennifer, Restifo, Nicholas P., Siegel, Richard M.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5196435/
https://ncbi.nlm.nih.gov/pubmed/28008916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13895
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