The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations

Heterozygous mutations of the receptor CD95 (Fas/Apo-1) are associated with defective lymphocyte apoptosis and a clinical disease characterized by lymphadenopathy, splenomegaly, and systemic autoimmunity. From our cohort of 11 families, we studied eight patients to define the mechanisms responsible...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Vaishnaw, Akshay K., Orlinick, Jason R., Chu, Jia-Li, Krammer, Peter H., Chao, Moses V., Elkon, Keith B.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1999
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Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC407903/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927496/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI5121
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