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The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations

Heterozygous mutations of the receptor CD95 (Fas/Apo-1) are associated with defective lymphocyte apoptosis and a clinical disease characterized by lymphadenopathy, splenomegaly, and systemic autoimmunity. From our cohort of 11 families, we studied eight patients to define the mechanisms responsible...

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Main Authors: Vaishnaw, Akshay K., Orlinick, Jason R., Chu, Jia-Li, Krammer, Peter H., Chao, Moses V., Elkon, Keith B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC407903/
https://ncbi.nlm.nih.gov/pubmed/9927496
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