Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia

Heterozygous mutations in the CD95 (APO-1/Fas) receptor occur in most individuals with autoimmune lymphoproliferative syndrome (ALPS) and dominantly interfere with apoptosis by an unknown mechanism. We show that local or global alterations in the structure of the cytoplasmic death domain from nine i...

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Detalhes bibliográficos
Main Authors: Martin, David A., Zheng, Lixin, Siegel, Richard M., Huang, Baohua, Fisher, Galen H., Wang, Jin, Jackson, Christine E., Puck, Jennifer M., Dale, Janet, Straus, Stephen E., Peter, Marcus E., Krammer, Peter H., Fesik, Stephen, Lenardo, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16370/
https://ncbi.nlm.nih.gov/pubmed/10200300
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