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Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia

Heterozygous mutations in the CD95 (APO-1/Fas) receptor occur in most individuals with autoimmune lymphoproliferative syndrome (ALPS) and dominantly interfere with apoptosis by an unknown mechanism. We show that local or global alterations in the structure of the cytoplasmic death domain from nine i...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Martin, David A., Zheng, Lixin, Siegel, Richard M., Huang, Baohua, Fisher, Galen H., Wang, Jin, Jackson, Christine E., Puck, Jennifer M., Dale, Janet, Straus, Stephen E., Peter, Marcus E., Krammer, Peter H., Fesik, Stephen, Lenardo, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16370/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10200300/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.8.4552
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