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Preparation of Enantiomerically Pure Perfluorobutanesulfinamide and Its Application to the Asymmetric Synthesis of α-Amino Acids

A high yielding and practical two-step synthesis of enantiomerically pure perfluorobutanesulfinamide from Senanayake’s 2-aminoindanol-derived sulfinyl transfer reagent was developed and carried out on multi-gram scale. Straightforward condensation of this sulfinamide with ethyl glyoxylate provided t...

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Publicat a:J Org Chem
Autors principals: Wangweerawong, Apiwat, Hummel, Joshua R., Bergman, Robert G., Ellman, Jonathan A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761297/
https://ncbi.nlm.nih.gov/pubmed/26844947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.5b02700
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