Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever

We studied the therapeutic potential of favipiravir (T-705) for Lassa fever, both alone and in combination with ribavirin. Favipiravir suppressed Lassa virus replication in cell culture by 5 log(10) units. In a novel lethal mouse model, it lowered the viremia level and the virus load in organs and n...

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Библиографические подробности
Опубликовано в: :J Infect Dis
Главные авторы: Oestereich, Lisa, Rieger, Toni, Lüdtke, Anja, Ruibal, Paula, Wurr, Stephanie, Pallasch, Elisa, Bockholt, Sabrina, Krasemann, Susanne, Muñoz-Fontela, César, Günther, Stephan
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Major Articles and Brief Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760419/
https://ncbi.nlm.nih.gov/pubmed/26531247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv522
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