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Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever
We studied the therapeutic potential of favipiravir (T-705) for Lassa fever, both alone and in combination with ribavirin. Favipiravir suppressed Lassa virus replication in cell culture by 5 log(10) units. In a novel lethal mouse model, it lowered the viremia level and the virus load in organs and n...
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| 出版年: | J Infect Dis |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4760419/ https://ncbi.nlm.nih.gov/pubmed/26531247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv522 |
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