Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever

We studied the therapeutic potential of favipiravir (T-705) for Lassa fever, both alone and in combination with ribavirin. Favipiravir suppressed Lassa virus replication in cell culture by 5 log(10) units. In a novel lethal mouse model, it lowered the viremia level and the virus load in organs and n...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:J Infect Dis
Hoofdauteurs: Oestereich, Lisa, Rieger, Toni, Lüdtke, Anja, Ruibal, Paula, Wurr, Stephanie, Pallasch, Elisa, Bockholt, Sabrina, Krasemann, Susanne, Muñoz-Fontela, César, Günther, Stephan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2016
Onderwerpen:
Major Articles and Brief Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760419/
https://ncbi.nlm.nih.gov/pubmed/26531247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv522
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items