Ebola Virus Disease in Mice with Transplanted Human Hematopoietic Stem Cells

The development of treatments for Ebola virus disease (EVD) has been hampered by the lack of small-animal models that mimick human disease. Here we show that mice with transplanted human hematopoetic stem cells reproduce features typical of EVD. Infection with Ebola virus was associated with viremia...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lüdtke, Anja, Oestereich, Lisa, Ruibal, Paula, Wurr, Stephanie, Pallasch, Elisa, Bockholt, Sabrina, Ip, Wing Hang, Rieger, Toni, Gómez-Medina, Sergio, Stocking, Carol, Rodríguez, Estefanía, Günther, Stephan, Muñoz-Fontela, César
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442348/
https://ncbi.nlm.nih.gov/pubmed/25673711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03546-14
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