Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever

BACKGROUND: Mice lacking the type I interferon receptor (IFNAR(−/−) mice) reproduce relevant aspects of Crimean-Congo hemorrhagic fever (CCHF) in humans, including liver damage. We aimed at characterizing the liver pathology in CCHF virus-infected IFNAR(−/−) mice by immunohistochemistry and employed...

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Detalhes bibliográficos
Main Authors: Oestereich, Lisa, Rieger, Toni, Neumann, Melanie, Bernreuther, Christian, Lehmann, Maria, Krasemann, Susanne, Wurr, Stephanie, Emmerich, Petra, de Lamballerie, Xavier, Ölschläger, Stephan, Günther, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006714/
https://ncbi.nlm.nih.gov/pubmed/24786461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002804
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