Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis

T-705 (favipiravir) is a new antiviral agent in advanced clinical development for influenza therapy. It is supposed to act as an alternative substrate for the viral polymerase, causing inhibition of viral RNA synthesis or virus mutagenesis. These mechanisms were also proposed for ribavirin, an estab...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Vanderlinden, Evelien, Vrancken, Bram, Van Houdt, Jeroen, Rajwanshi, Vivek K., Gillemot, Sarah, Andrei, Graciela, Lemey, Philippe, Naesens, Lieve
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075073/
https://ncbi.nlm.nih.gov/pubmed/27572398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01156-16
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