Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy

Eukaryotic elongation factor 2 kinase (eEF2K) inhibits the elongation stage of protein synthesis by phosphorylating its only known substrate, eEF2. eEF2K is tightly regulated by nutrient-sensitive signalling pathways. For example, it is inhibited by signalling through mammalian target of rapamycin c...

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Detalhes bibliográficos
Publicado no:Cell Signal
Main Authors: Moore, Claire E.J., Wang, Xuemin, Xie, Jianling, Pickford, Jo, Barron, John, Regufe da Mota, Sergio, Versele, Matthias, Proud, Christopher G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Ltd 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760274/
https://ncbi.nlm.nih.gov/pubmed/26795954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2016.01.005
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