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Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia

Protein synthesis, especially translation elongation, requires large amounts of energy, which is often generated by oxidative metabolism. Elongation is controlled by phosphorylation of eukaryotic elongation factor 2 (eEF2), which inhibits its activity and is catalyzed by eEF2 kinase (eEF2K), a calci...

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Détails bibliographiques
Publié dans:Mol Cell Biol
Auteurs principaux: Moore, Claire E. J., Mikolajek, Halina, Regufe da Mota, Sergio, Wang, Xuemin, Kenney, Justin W., Werner, Jörn M., Proud, Christopher G.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405635/
https://ncbi.nlm.nih.gov/pubmed/25755286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01457-14
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