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Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia

Protein synthesis, especially translation elongation, requires large amounts of energy, which is often generated by oxidative metabolism. Elongation is controlled by phosphorylation of eukaryotic elongation factor 2 (eEF2), which inhibits its activity and is catalyzed by eEF2 kinase (eEF2K), a calci...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Moore, Claire E. J., Mikolajek, Halina, Regufe da Mota, Sergio, Wang, Xuemin, Kenney, Justin W., Werner, Jörn M., Proud, Christopher G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405635/
https://ncbi.nlm.nih.gov/pubmed/25755286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01457-14
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