High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia

The TP73 gene transcript is alternatively spliced and translated into the transcriptionally active (TAp73) or inactive (ΔNp73) isoforms, with opposite effects on the expression of p53 target genes and on apoptosis induction. The imbalance between ΔNp73 and TAp73 may contribute to tumorigenesis and r...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood
Egile Nagusiak: Lucena-Araujo, Antonio R., Kim, Haesook T., Thomé, Carolina, Jacomo, Rafael H., Melo, Raul A., Bittencourt, Rosane, Pasquini, Ricardo, Pagnano, Katia, Glória, Ana Beatriz F., Chauffaille, Maria de Lourdes, Athayde, Melina, Chiattone, Carlos S., Mito, Ingrid, Bendlin, Rodrigo, Souza, Carmino, Bortolheiro, Cristina, Coelho-Silva, Juan L., Schrier, Stanley L., Tallman, Martin S., Grimwade, David, Ganser, Arnold, Berliner, Nancy, Ribeiro, Raul C., Lo-Coco, Francesco, Löwenberg, Bob, Sanz, Miguel A., Rego, Eduardo M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2015
Gaiak:
Myeloid Neoplasia
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760128/
https://ncbi.nlm.nih.gov/pubmed/26429976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-623330
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