High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia

The TP73 gene transcript is alternatively spliced and translated into the transcriptionally active (TAp73) or inactive (ΔNp73) isoforms, with opposite effects on the expression of p53 target genes and on apoptosis induction. The imbalance between ΔNp73 and TAp73 may contribute to tumorigenesis and r...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Lucena-Araujo, Antonio R., Kim, Haesook T., Thomé, Carolina, Jacomo, Rafael H., Melo, Raul A., Bittencourt, Rosane, Pasquini, Ricardo, Pagnano, Katia, Glória, Ana Beatriz F., Chauffaille, Maria de Lourdes, Athayde, Melina, Chiattone, Carlos S., Mito, Ingrid, Bendlin, Rodrigo, Souza, Carmino, Bortolheiro, Cristina, Coelho-Silva, Juan L., Schrier, Stanley L., Tallman, Martin S., Grimwade, David, Ganser, Arnold, Berliner, Nancy, Ribeiro, Raul C., Lo-Coco, Francesco, Löwenberg, Bob, Sanz, Miguel A., Rego, Eduardo M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760128/
https://ncbi.nlm.nih.gov/pubmed/26429976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-623330
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