Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

BACKGROUND: Aggregation of malformed proteins is a key feature of many neurodegenerative diseases, but the mechanisms that drive proteinopathy in the brain are poorly understood. We aimed to characterize aggregated proteins in human brain tissues affected by dementia. RESULTS: To characterize amyloi...

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Bibliografiske detaljer
Udgivet i:Mol Brain
Main Authors: Adav, Sunil S., Gallart-Palau, Xavier, Tan, Kok Hian, Lim, Sai Kiang, Tam, James P., Sze, Siu Kwan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Methodology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759965/
https://ncbi.nlm.nih.gov/pubmed/26892330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-016-0200-z
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