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Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

BACKGROUND: Aggregation of malformed proteins is a key feature of many neurodegenerative diseases, but the mechanisms that drive proteinopathy in the brain are poorly understood. We aimed to characterize aggregated proteins in human brain tissues affected by dementia. RESULTS: To characterize amyloi...

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Detalhes bibliográficos
Publicado no:Mol Brain
Main Authors: Adav, Sunil S., Gallart-Palau, Xavier, Tan, Kok Hian, Lim, Sai Kiang, Tam, James P., Sze, Siu Kwan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759965/
https://ncbi.nlm.nih.gov/pubmed/26892330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-016-0200-z
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