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Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

BACKGROUND: Aggregation of malformed proteins is a key feature of many neurodegenerative diseases, but the mechanisms that drive proteinopathy in the brain are poorly understood. We aimed to characterize aggregated proteins in human brain tissues affected by dementia. RESULTS: To characterize amyloi...

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Bibliografische gegevens
Gepubliceerd in:Mol Brain
Hoofdauteurs: Adav, Sunil S., Gallart-Palau, Xavier, Tan, Kok Hian, Lim, Sai Kiang, Tam, James P., Sze, Siu Kwan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759965/
https://ncbi.nlm.nih.gov/pubmed/26892330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-016-0200-z
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