New Tris(hydroxypyridinone) Bifunctional Chelators Containing Isothiocyanate Groups Provide a Versatile Platform for Rapid One-Step Labeling and PET Imaging with (68)Ga(3+)

[Image: see text] Two new bifunctional tris(hydroxypyridinone) (THP) chelators designed specifically for rapid labeling with (68)Ga have been synthesized, each with pendant isothiocyanate groups and three 1,6-dimethyl-3-hydroxypyridin-4-one groups. Both compounds have been conjugated with the primar...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Ma, Michelle T., Cullinane, Carleen, Imberti, Cinzia, Baguña Torres, Julia, Terry, Samantha Y. A., Roselt, Peter, Hicks, Rodney J., Blower, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759618/
https://ncbi.nlm.nih.gov/pubmed/26286399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00335
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