Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer’s Disease?

[Image: see text] Amyloid β peptide (Aβ42) assemblies are considered central to the development of Alzheimer’s disease, but the mechanism of this toxicity remains unresolved. We screened protein microarrays with on-pathway oligomeric Aβ42 to identify candidate proteins interacting with toxic Aβ42 sp...

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Vydáno v:ACS Chem Neurosci
Hlavní autoři: Dunning, Christopher J., McGauran, Gavin, Willén, Katarina, Gouras, Gunnar K., O’Connell, David J., Linse, Sara
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759616/
https://ncbi.nlm.nih.gov/pubmed/26618561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00262
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