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Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer’s Disease?
[Image: see text] Amyloid β peptide (Aβ42) assemblies are considered central to the development of Alzheimer’s disease, but the mechanism of this toxicity remains unresolved. We screened protein microarrays with on-pathway oligomeric Aβ42 to identify candidate proteins interacting with toxic Aβ42 sp...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ACS Chem Neurosci |
|---|---|
| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical
Society
2015
|
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4759616/ https://ncbi.nlm.nih.gov/pubmed/26618561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00262 |
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