Potential role of AKT/mTOR signalling proteins in hairy cell leukaemia: association with BRAF/ERK activation and clinical outcome

The potential role of AKT/mTOR signalling proteins and its association with the Raf-MEK-ERK pathway was investigated in hairy cell leukaemia (HCL). BRAFV600E expression and activated forms of AKT, mTOR, ERK1/2, p70S6k and 4E-BP1 were immunohistochemically assessed in 77 BM biopsies of HCL patients a...

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Pubblicato in:Sci Rep
Autori principali: Lakiotaki, Eleftheria, Levidou, Georgia, Angelopoulou, Maria K., Adamopoulos, Christos, Pangalis, Gerassimos, Rassidakis, George, Vassilakopoulos, Theodoros, Gainaru, Gabriella, Flevari, Pagona, Sachanas, Sotirios, Saetta, Angelica A., Sepsa, Athanasia, Moschogiannis, Maria, Kalpadakis, Christina, Tsesmetzis, Nikolaos, Milionis, Vassilios, Chatziandreou, Ilenia, Thymara, Irene, Panayiotidis, Panayiotis, Dimopoulou, Maria, Plata, Eleni, Konstantopoulos, Konstantinos, Patsouris, Efstratios, Piperi, Christina, Korkolopoulou, Penelope
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759548/
https://ncbi.nlm.nih.gov/pubmed/26893254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21252
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