The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas

Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are “endowed” with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcino...

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Bibliographic Details
Main Authors: El Habr, Elias A., Adamopoulos, Christos, Levidou, Georgia, Saetta, Aggeliki A., Korkolopoulou, Penelope, Piperi, Christina
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316974/
https://ncbi.nlm.nih.gov/pubmed/22530122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/454957
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