Potential role of AKT/mTOR signalling proteins in hairy cell leukaemia: association with BRAF/ERK activation and clinical outcome

The potential role of AKT/mTOR signalling proteins and its association with the Raf-MEK-ERK pathway was investigated in hairy cell leukaemia (HCL). BRAFV600E expression and activated forms of AKT, mTOR, ERK1/2, p70S6k and 4E-BP1 were immunohistochemically assessed in 77 BM biopsies of HCL patients a...

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Publicat a:Sci Rep
Autors principals: Lakiotaki, Eleftheria, Levidou, Georgia, Angelopoulou, Maria K., Adamopoulos, Christos, Pangalis, Gerassimos, Rassidakis, George, Vassilakopoulos, Theodoros, Gainaru, Gabriella, Flevari, Pagona, Sachanas, Sotirios, Saetta, Angelica A., Sepsa, Athanasia, Moschogiannis, Maria, Kalpadakis, Christina, Tsesmetzis, Nikolaos, Milionis, Vassilios, Chatziandreou, Ilenia, Thymara, Irene, Panayiotidis, Panayiotis, Dimopoulou, Maria, Plata, Eleni, Konstantopoulos, Konstantinos, Patsouris, Efstratios, Piperi, Christina, Korkolopoulou, Penelope
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759548/
https://ncbi.nlm.nih.gov/pubmed/26893254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21252
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