Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin Protein

Cataract is a protein misfolding disease where the size of the aggregate is directly related to the severity of the disorder. However, the molecular mechanisms that trigger the onset of aggregation remain unknown. Here we use a combination of protein engineering techniques and single-molecule force...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Garcia-Manyes, Sergi, Giganti, David, Badilla, Carmen L., Lezamiz, Ainhoa, Perales-Calvo, Judit, Beedle, Amy E. M., Fernández, Julio M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Molecular Biophysics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759196/
https://ncbi.nlm.nih.gov/pubmed/26703476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.673871
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