A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer

Wnt/β-catenin signaling is required for crypt structure maintenance. We previously observed nuclear accumulation of Ser-552 phosphorylated β-catenin (pβ-Cat(Ser-552)) in intestinal epithelial cells (IEC) during colitis and colitis-associated cancer. Data here delineate a novel multiprotein cytosolic...

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Vydáno v:J Biol Chem
Hlavní autoři: Goretsky, Tatiana, Bradford, Emily M., Ryu, Hyunji, Tahir, Maryam, Moyer, Mary Pat, Gao, Tianyan, Li, Linheng, Barrett, Terrence A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759191/
https://ncbi.nlm.nih.gov/pubmed/26565021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.669416
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