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Cytochrome P450 17A1 Interactions with the FMN Domain of Its Reductase as Characterized by NMR

To accomplish key physiological processes ranging from drug metabolism to steroidogenesis, human microsomal cytochrome P450 enzymes require the sequential input of two electrons delivered by the FMN domain of NADPH-cytochrome P450 reductase. Although some human microsomal P450 enzymes can instead ac...

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Publicado en:J Biol Chem
Main Authors: Estrada, D. Fernando, Laurence, Jennifer S., Scott, Emily E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759177/
https://ncbi.nlm.nih.gov/pubmed/26719338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677294
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