Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

Although there has been extensive characterization of the Wnt signaling pathway in the osteoblast lineage, the effects of Wnt proteins on the osteoclast lineage are less well studied. We found that osteoclast lineage cells express canonical Wnt receptors. Wnt3a reduced osteoclast formation when appl...

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Vydáno v:J Bone Miner Res
Hlavní autoři: Weivoda, Megan M, Ruan, Ming, Hachfeld, Christine M, Pederson, Larry, Howe, Alan, Davey, Rachel A, Zajac, Jeffrey D, Kobayashi, Yasuhiro, Williams, Bart O, Westendorf, Jennifer J, Khosla, Sundeep, Oursler, Merry Jo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758681/
https://ncbi.nlm.nih.gov/pubmed/26189772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2599
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