Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

Although there has been extensive characterization of the Wnt signaling pathway in the osteoblast lineage, the effects of Wnt proteins on the osteoclast lineage are less well studied. We found that osteoclast lineage cells express canonical Wnt receptors. Wnt3a reduced osteoclast formation when appl...

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Bibliografiske detaljer
Udgivet i:J Bone Miner Res
Main Authors: Weivoda, Megan M, Ruan, Ming, Hachfeld, Christine M, Pederson, Larry, Howe, Alan, Davey, Rachel A, Zajac, Jeffrey D, Kobayashi, Yasuhiro, Williams, Bart O, Westendorf, Jennifer J, Khosla, Sundeep, Oursler, Merry Jo
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758681/
https://ncbi.nlm.nih.gov/pubmed/26189772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2599
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