Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

The blood–brain barrier (BBB) limits the entry of neurotoxic blood-derived products and cells into the brain that is required for normal neuronal functioning and information processing. Pericytes maintain the integrity of the BBB and degenerate in Alzheimer’s disease (AD). The BBB is damaged in AD,...

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Pubblicato in:J Cereb Blood Flow Metab
Autori principali: Halliday, Matthew R, Rege, Sanket V, Ma, Qingyi, Zhao, Zhen, Miller, Carol A, Winkler, Ethan A, Zlokovic, Berislav V
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2016
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758554/
https://ncbi.nlm.nih.gov/pubmed/25757756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.44
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