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Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

The blood–brain barrier (BBB) limits the entry of neurotoxic blood-derived products and cells into the brain that is required for normal neuronal functioning and information processing. Pericytes maintain the integrity of the BBB and degenerate in Alzheimer’s disease (AD). The BBB is damaged in AD,...

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Detalles Bibliográficos
Publicado en:J Cereb Blood Flow Metab
Main Authors: Halliday, Matthew R, Rege, Sanket V, Ma, Qingyi, Zhao, Zhen, Miller, Carol A, Winkler, Ethan A, Zlokovic, Berislav V
Formato: Artigo
Idioma:Inglês
Publicado: SAGE Publications 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758554/
https://ncbi.nlm.nih.gov/pubmed/25757756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.44
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