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Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1α activation

Alcohol-related hepatocellular carcinoma (HCC) develops with advanced alcoholic liver disease and liver fibrosis. Using adult mice, we evaluate the effect of alcoholic steatohepatitis on early hepatobiliary carcinoma after initiation by diethyl-nitrosamine (DEN). Here we show that alcohol-fed DEN-in...

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Publicat a:Sci Rep
Autors principals: Ambade, Aditya, Satishchandran, Abhishek, Szabo, Gyongyi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758032/
https://ncbi.nlm.nih.gov/pubmed/26888602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21340
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