Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

N-Myristoyltransferase (NMT) represents an attractive drug target in parasitic infections such as malaria due to its genetic essentiality and amenability to inhibition by drug-like small molecules. Scaffold simplification from previously reported inhibitors containing bicyclic cores identified pheny...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Yu, Zhiyong, Brannigan, James A., Rangachari, Kaveri, Heal, William P., Wilkinson, Anthony J., Holder, Anthony A., Leatherbarrow, Robin J., Tate, Edward W.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757856/
https://ncbi.nlm.nih.gov/pubmed/26962430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5md00242g
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados