Increased bone density in mice lacking the proton receptor, OGR1

Chronic metabolic acidosis stimulates cell-mediated calcium efflux from bone through osteoblastic prostaglandin E2-induced stimulation of RANKL leading to increased osteoclastic bone resorption. Osteoblasts express the proton-sensing G-protein coupled receptor, OGR1, which activates IP3-mediated int...

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Bibliographic Details
Published in:Kidney Int
Main Authors: Krieger, Nancy S., Yao, Zhenqiang, Kyker-Snowman, Kelly, Kim, Min Ho, Boyce, Brendan F., Bushinsky, David A.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757816/
https://ncbi.nlm.nih.gov/pubmed/26880453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2015.12.020
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