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Increased bone density in mice lacking the proton receptor, OGR1
Chronic metabolic acidosis stimulates cell-mediated calcium efflux from bone through osteoblastic prostaglandin E2-induced stimulation of RANKL leading to increased osteoclastic bone resorption. Osteoblasts express the proton-sensing G-protein coupled receptor, OGR1, which activates IP3-mediated int...
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| Publicado no: | Kidney Int |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4757816/ https://ncbi.nlm.nih.gov/pubmed/26880453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2015.12.020 |
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