Synthesis and Evaluation of Orally Active Small Molecule HIV-1 Nef Antagonists

The HIV-1 Nef accessory factor enhances viral replication and promotes immune system evasion of HIV-infected cells, making it an attractive target for drug discovery. Recently we described a novel class of diphenylpyrazolodiazene compounds that bind directly to Nef in vitro and inhibit Nef-dependent...

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發表在:Bioorg Med Chem Lett
Main Authors: Emert-Sedlak, Lori A., Loughran, H. Marie, Shi, Haibin, Kulp, John L., Shu, Sherry T., Zhao, Jielu, Day, Billy W., Wrobel, Jay E., Reitz, Allen B., Smithgall, Thomas E.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756635/
https://ncbi.nlm.nih.gov/pubmed/26852364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.01.043
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