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Synthesis and Evaluation of Orally Active Small Molecule HIV-1 Nef Antagonists

The HIV-1 Nef accessory factor enhances viral replication and promotes immune system evasion of HIV-infected cells, making it an attractive target for drug discovery. Recently we described a novel class of diphenylpyrazolodiazene compounds that bind directly to Nef in vitro and inhibit Nef-dependent...

詳細記述

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書誌詳細
出版年:Bioorg Med Chem Lett
主要な著者: Emert-Sedlak, Lori A., Loughran, H. Marie, Shi, Haibin, Kulp, John L., Shu, Sherry T., Zhao, Jielu, Day, Billy W., Wrobel, Jay E., Reitz, Allen B., Smithgall, Thomas E.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756635/
https://ncbi.nlm.nih.gov/pubmed/26852364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.01.043
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