Physiological evidence for diversification of IFNα- and IFNβ-mediated response programs in different autoimmune diseases

BACKGROUND: Activation of the type I interferon (IFN) response program is described for several autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS), myositis (IIM) and rheumatoid arthritis (RA). While IFNα contributes to SLE pathology, IFNβ therapy is often ben...

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Publicado en:Arthritis Res Ther
Main Authors: de Jong, Tamarah D., Vosslamber, Saskia, Mantel, Elise, de Ridder, Sander, Wesseling, John G., van der Pouw Kraan, Tineke C. T. M., Leurs, Cyra, Hegen, Harald, Deisenhammer, Florian, Killestein, Joep, Lundberg, Ingrid E., Vencovsky, Jiri, Nurmohamed, Mike T., van Schaardenburg, Dirkjan, Bultink, Irene E. M., Voskuyl, Alexandre E., Pegtel, D. Michiel, van der Laken, Conny J., Bijlsma, Johannes W. J., Verweij, Cornelis L.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756531/
https://ncbi.nlm.nih.gov/pubmed/26882897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0946-9
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