Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice

Altered function of the Gq-coupled, Group 1 metabotropic glutamate receptors, specifically mGlu5, is implicated in multiple mouse models of autism and intellectual disability. mGlu5 dysfunction has been most well characterized in the fragile X syndrome mouse model, the Fmr1 knock-out (KO) mouse, whe...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Guo, Weirui, Molinaro, Gemma, Collins, Katie A., Hays, Seth A., Paylor, Richard, Worley, Paul F., Szumlinski, Karen K., Huber, Kimberly M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756152/
https://ncbi.nlm.nih.gov/pubmed/26888925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2921-15.2016
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