Disrupted mGluR5-Homer scaffolds mediate abnormal mGluR5 signaling, circuit function and behavior in a mouse model of Fragile X Syndrome

Enhanced mGluR5 function is causally associated with the pathophysiology of Fragile X Syndrome (FXS), a leading inherited cause of intellectual disability and autism. Here we provide evidence that altered mGluR5-Homer scaffolds contribute to mGluR5 dysfunction and phenotypes in the FXS mouse model,...

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Détails bibliographiques
Auteurs principaux: Ronesi, Jennifer A., Collins, Katie A., Hays, Seth A., Tsai, Nien-Pei, Guo, Weirui, Birnbaum, Shari G., Hu, Jia-Hua, Worley, Paul F., Gibson, Jay R., Huber, Kimberly M.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288402/
https://ncbi.nlm.nih.gov/pubmed/22267161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3033
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