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A beta-blocker, propranolol, decreases the efficacy from enzyme replacement therapy in Pompe disease

Enzyme replacement therapy (ERT) with recombinant human acid α-glucosidase (rhGAA) fails to completely reverse muscle weakness in Pompe disease. β2-agonists enhanced ERT by increasing receptor-mediated uptake of rhGAA in skeletal muscles. PURPOSE: To test the hypothesis that a β-blocker might reduce...

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Podrobná bibliografie
Vydáno v:Mol Genet Metab
Hlavní autoři: Han, Sang-oh, Pope, Rand, Li, Songtao, Kishnani, Priya S., Steet, Richard, Koeberl, Dwight D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755835/
https://ncbi.nlm.nih.gov/pubmed/26454691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2015.09.012
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