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A beta-blocker, propranolol, decreases the efficacy from enzyme replacement therapy in Pompe disease
Enzyme replacement therapy (ERT) with recombinant human acid α-glucosidase (rhGAA) fails to completely reverse muscle weakness in Pompe disease. β2-agonists enhanced ERT by increasing receptor-mediated uptake of rhGAA in skeletal muscles. PURPOSE: To test the hypothesis that a β-blocker might reduce...
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| Publicado no: | Mol Genet Metab |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4755835/ https://ncbi.nlm.nih.gov/pubmed/26454691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2015.09.012 |
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