Chimeric Vaccine Stimulation of Human Dendritic Cell Indoleamine 2, 3-Dioxygenase Occurs via the Non-Canonical NF-κB Pathway

A chimeric protein vaccine composed of the cholera toxin B subunit fused to proinsulin (CTB-INS) was shown to suppress type 1 diabetes onset in NOD mice and upregulate biosynthesis of the tryptophan catabolic enzyme indoleamine 2, 3-dioxygenase (IDO1) in human dendritic cells (DCs). Here we demonstr...

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Publicado en:PLoS One
Main Authors: Kim, Nan-Sun, Mbongue, Jacques C., Nicholas, Dequina A., Esebanmen, Grace E., Unternaehrer, Juli J., Firek, Anthony F., Langridge, William H. R.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755608/
https://ncbi.nlm.nih.gov/pubmed/26881431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147509
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