The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity

Indoleamine 2, 3-dioxygenase (IDO) is the first and rate limiting catabolic enzyme in the degradation pathway of the essential amino acid tryptophan. By cleaving the aromatic indole ring of tryptophan, IDO initiates the production of a variety of tryptophan degradation products called “kynurenines”...

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Detalhes bibliográficos
Publicado no:Vaccines (Basel)
Main Authors: Mbongue, Jacques C., Nicholas, Dequina A., Torrez, Timothy W., Kim, Nan-Sun, Firek, Anthony F., Langridge, William H.R.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586474/
https://ncbi.nlm.nih.gov/pubmed/26378585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines3030703
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