The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity

Indoleamine 2, 3-dioxygenase (IDO) is the first and rate limiting catabolic enzyme in the degradation pathway of the essential amino acid tryptophan. By cleaving the aromatic indole ring of tryptophan, IDO initiates the production of a variety of tryptophan degradation products called “kynurenines”...

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Dettagli Bibliografici
Pubblicato in:Vaccines (Basel)
Autori principali: Mbongue, Jacques C., Nicholas, Dequina A., Torrez, Timothy W., Kim, Nan-Sun, Firek, Anthony F., Langridge, William H.R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2015
Soggetti:
Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586474/
https://ncbi.nlm.nih.gov/pubmed/26378585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines3030703
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