Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin

The plant secondary metabolite and common food additive dihydrocoumarin (DHC) is an inhibitor of the Sirtuin family of NAD(+)-dependent deacetylases. Sirtuins are key regulators of epigenetic processes that maintain silent chromatin in yeast and have been linked to gene expression, metabolism, apopt...

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Pubblicato in:PLoS One
Autori principali: Jacobi, Jennifer L., Yang, Bo, Li, Xu, Menze, Anna K., Laurentz, Sara M., Janle, Elsa M., Ferruzzi, Mario G., McCabe, George P., Chapple, Clint, Kirchmaier, Ann L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755582/
https://ncbi.nlm.nih.gov/pubmed/26882112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149207
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