Elevated Tonic Extracellular Dopamine Concentration and Altered Dopamine Modulation of Synaptic Activity Precede Dopamine Loss in the Striatum of Mice Overexpressing Human α-Synuclein

Overexpression or mutation of α-synuclein (α-Syn), a protein associated with presynaptic vesicles, causes familial forms of Parkinson’s disease in humans and is also associated with sporadic forms of the disease. We used in vivo microdialysis, tissue content analysis, behavioral assessment, and whol...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Neurosci Res
मुख्य लेखकों: Lam, Hoa A., Wu, Nanping, Cely, Ingrid, Kelly, Rachel L., Hean, Sindalana, Richter, Franziska, Magen, Iddo, Cepeda, Carlos, Ackerson, Larry C., Walwyn, Wendy, Masliah, Eliezer, Chesselet, Marie-Françoise, Levine, Michael S., Maidment, Nigel T.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2011
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755488/
https://ncbi.nlm.nih.gov/pubmed/21488084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.22611
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