Elevated Tonic Extracellular Dopamine Concentration and Altered Dopamine Modulation of Synaptic Activity Precede Dopamine Loss in the Striatum of Mice Overexpressing Human α-Synuclein

Overexpression or mutation of α-synuclein (α-Syn), a protein associated with presynaptic vesicles, causes familial forms of Parkinson’s disease in humans and is also associated with sporadic forms of the disease. We used in vivo microdialysis, tissue content analysis, behavioral assessment, and whol...

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Detalhes bibliográficos
Publicado no:J Neurosci Res
Main Authors: Lam, Hoa A., Wu, Nanping, Cely, Ingrid, Kelly, Rachel L., Hean, Sindalana, Richter, Franziska, Magen, Iddo, Cepeda, Carlos, Ackerson, Larry C., Walwyn, Wendy, Masliah, Eliezer, Chesselet, Marie-Françoise, Levine, Michael S., Maidment, Nigel T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755488/
https://ncbi.nlm.nih.gov/pubmed/21488084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.22611
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