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ALPHA-SYNUCLEIN OVEREXPRESSION IN MICE ALTERS SYNAPTIC COMMUNICATION IN THE CORTICOSTRIATAL PATHWAY
α-Synuclein (α-Syn) is a presynaptic protein implicated in Parkinson’s disease (PD). Mice overexpressing human wildtype (WT) α-Syn under the Thy1 promoter show high levels of α-Syn in cortical and subcortical regions, exhibit progressive sensorimotor anomalies, as well as non-motor abnormalities and...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3707301/ https://ncbi.nlm.nih.gov/pubmed/20029978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.22327 |
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